Acetic acid 1H-indol-4-yl ester
4-indolyl acetate
CAS: 5585-96-6
Molecular Formula: C10H9NO2
Acetic acid 1H-indol-4-yl ester - Names and Identifiers
| Name | 4-indolyl acetate |
| Synonyms | ACETOXYINDOLE 4-ACETOXYINDOLE 4-Acetoxyindole 4-indolyl acetate 4-INDOLYL ACETATE 4-INDOXYL ACETATE 4-Indoxyl acetate 4-Acetoxy-1H-indole 1H-indol-4-yl acetate 1H-Indol-4-ol,4-acetate Acetic acid 1H-indol-4-yl ester |
| CAS | 5585-96-6 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C10H9NO2/c1-7(12)13-10-4-2-3-9-8(10)5-6-11-9/h2-6,11H,1H3 |
| InChIKey | ZXDMUHFTJWEDEF-UHFFFAOYSA-N |
Acetic acid 1H-indol-4-yl ester - Physico-chemical Properties
| Molecular Formula | C10H9NO2 |
| Molar Mass | 175.18 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Melting Point | 100-102°C |
| Boling Point | 339.1±15.0 °C(Predicted) |
| Flash Point | 158.9°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 9.41E-05mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White to Beige |
| pKa | 16.38±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.633 |
| MDL | MFCD00010678 |
Acetic acid 1H-indol-4-yl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Note | Irritant |
Acetic acid 1H-indol-4-yl ester - Reference Information
| Use | 4-acetoxyindole is an organic intermediate, it can be obtained by acylation of 4-hydroxyindole with acetic anhydride. |
| preparation | 4-hydroxyindole (1 equivalent of the limiting reagent) was loaded into a vessel under N2, DCM (dichloromethane; 6 volumes based on 4-hydroxyindole loading) was then loaded. The reaction was cooled to 0-5 °c and pyridine (1.2 eq.) was added dropwise at 0-5 °c. Acetic anhydride (1.1 equiv.) was added dropwise at 0-5 °c and the reaction was warmed to 20-25 °c for 1-1.5 hours and stirred at 20-25 °c for an additional 3 hours. The reaction was sampled and analyzed for completion. The reaction was then washed three times with a 20% aqueous citric acid solution (based on 4-hydroxyindole loading, 3x 3 volumes) and with saturated NaHCO3 (based on 4-hydroxyindole loading, 3 volumes) wash once. The DCM solution was dried over MgSO4 and filtered, and the DCM layer was concentrated to half volume by distillation. Heptane (6 vol based on 4-hydroxyindole loading) was added and additional DCM was removed by distillation until complete precipitation of stage 1 occurred. The reaction was cooled to 15-25 °c and the solid was collected by filtration, washed with heptane (1 Vol based on 4-hydroxyindole loading), drying at 60 °c under vacuum overnight gave 4-acetoxyindole. |
Last Update：2024-04-09 02:00:09
Supplier List
Featured Products
Product Name: 4-Acetoxyindole Request for quotationCAS: 5585-96-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-18162425036
Email: 3866263148@qq.com
Mobile: 18162425036
QQ: 3866263148
Wechat: 18162425036
Product Name: 4-indolyl acetate Request for quotation
CAS: 5585-96-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 5585-96-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 4-Acetoxyindole Visit Supplier Webpage Request for quotation
CAS: 5585-96-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 5585-96-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured Products
Product Name: 4-Acetoxyindole Request for quotationCAS: 5585-96-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-18162425036
Email: 3866263148@qq.com
Mobile: 18162425036
QQ: 3866263148
Wechat: 18162425036
Product Name: 4-indolyl acetate Request for quotation
CAS: 5585-96-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 5585-96-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 4-indolyl acetate Request for quotationCAS: 5585-96-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 4-Indolyl acetate Visit Supplier Webpage Request for quotationCAS: 5585-96-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 4-Acetoxyindole Visit Supplier Webpage Request for quotation
CAS: 5585-96-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 5585-96-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Acetic acid 1H-indol-4-yl ester
嘧苯十六铵
3-氨基-2-噁唑烷酮
Imidazo[1,5-a]pyrazin-3(2H)-one, hexahydro-2-[3-(methylthio)phenyl]-, hydrochloride (1:1)
3,5-di-tert-butyl-4-hydroxyphenylpropionic acid (3,5-DTBHA)
树脂助剂1115酯,羟基特戊酸新戊二醇酯
Methyl 5-chloro-2-methoxy-4-methylbenzoate
5-乙酰基-1H-吲哚-2-羧酸乙酯
{2-[(3-氯苄基)硫代]乙基}胺
3-[4-(2-Butyl-4-chloro-5-methoxymethyl-1H-imidazol-1-ylmethyl)phenylaminocarbonyl]-2-phenylpropionic acid
嘧苯十六铵
3-氨基-2-噁唑烷酮
Imidazo[1,5-a]pyrazin-3(2H)-one, hexahydro-2-[3-(methylthio)phenyl]-, hydrochloride (1:1)
3,5-di-tert-butyl-4-hydroxyphenylpropionic acid (3,5-DTBHA)
树脂助剂1115酯,羟基特戊酸新戊二醇酯
Methyl 5-chloro-2-methoxy-4-methylbenzoate
5-乙酰基-1H-吲哚-2-羧酸乙酯
{2-[(3-氯苄基)硫代]乙基}胺
3-[4-(2-Butyl-4-chloro-5-methoxymethyl-1H-imidazol-1-ylmethyl)phenylaminocarbonyl]-2-phenylpropionic acid